HIV and human endogenous retroviruses: an hypothesis with therapeutic implications.
نویسندگان
چکیده
منابع مشابه
Endogenous Retroviruses and the Human Genome: Implications for Human Disease
Introduction Lifecycle and Genome Organization Endogenization Process and Host-Virus Evolution Classification of HERVs HERV Manipulation of Host Function Host Defenses against HERVs Cancer Multiple Sclerosis Schizophrenia Azoospermia Conclusions Sources Abstract Human endogenous retroviruses (HERVs) constitute approximately 8% of the human genome (16, 22, 39, 55). These ancient retroviruses rep...
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Human endogenous retroviruses (HERVs) are retroviruses that infected human genome millions of years ago and have persisted throughout human evolution. About 8% of our genome is composed of HERVs, most of which are nonfunctional because of epigenetic control or deactivating mutations. However, a correlation between HERVs and human cancer has been described and many tumors, such as melanoma, brea...
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Humans share about 99% of their genomic DNA with chimpanzees and bonobos; thus, the differences between these species are unlikely to be in gene content but could be caused by inherited changes in regulatory systems. Endogenous retroviruses (ERVs) comprise approximately 5% of the human genome. The LTRs of ERVs contain many regulatory sequences, such as promoters, enhancers, polyadenylation sign...
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A number of observations have led researchers to postulate that, despite being replication-defective, human endogenous retroviruses (HERVs) may have retained the potential to cause or contribute to disease. However, mechanisms of HERV pathogenicity might differ substantially from those of modern infectious retroviruses or of the infectious precursors of HERVs. Therefore, novel pathways of HERV ...
متن کاملHuman endogenous retroviruses: nature, occurrence, and clinical implications in human disease.
Retroviral diagnostics have become standard in human laboratory medicine. While current emphasis is placed on the human exogenous viruses (human immunodeficiency virus and human T-cell leukemia virus), evidence implicating human endogenous retroviruses (HERVs) in various human disease entities continues to mount. Literature on the occurrence of HERVs in human tissues and cells was analyzed. Sub...
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ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 1996
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.1996_4454